Since I started developing Curcumall I am always amazed from the wide range of health conditions that curcumin can alleviate. This blog will deal with Alzheimer's disease (AD) and curcumin.
Alzheimer's disease (AD) involves amyloid beta accumulation in the brain, oxidative damage, and inflammation. Curcumin has anti-oxidant, anti-inflammatory and cholesterol lowering properties, all three of which are believed to be key processes involved in the pathogenesis of AD.
Research has shown that the risk of getting AD is reduced with increased antioxidant and anti-inflammatory consumption. Since curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage and inflammation, it was found that supplementation of curcumin in patients with AD, may inhibit the progression of AD. http://alzheimer.neurology.ucla.edu/pubs/RingmanCurc2005MedChem.pdf
There are a few suggested mechanisms explaining curcumin's activity in AD patients that may inhibit cognitive deficits:
Curcumin was shown to inhibit amyloid accumulation. The peptide called amyloid beta forms aggregates in the brain of AD patients, deposits known as amyloid plaques. Curcumin inhibits the formation of amyloid beta, binds the plaques and thus reduces the amyloid in the brain. http://www.ncbi.nlm.nih.gov/pubmed/15590663
Another research has shown that curcumin helps AD patients by enhancing the natural function of the immune system. Curcumin improved ingestion of amyloid beta by boosting the activity of the immune cells called macrophages. Macrophages are immune system's cells that travel through the body and the brain gobbling up waste products, including amyloid beta. Curcumin may support the body's natural immune fighting function in directly helping the macrophages.
http://www.naturalnews.com/021157_disease_Alzheimers_Alzheimers_disease.html
A third approach has shown that curcumin may reduce amyloid aggregation by a mechanism of metal chelation. As metals can induce amyloid beta aggregation and toxicity and are concentrated in AD brains, curcumin might exert a net protective effect against the amyloid toxicity or might suppress inflammatory damage by preventing metal induction of NF-κB.
http://iospress.metapress.com/content/yy1rf8ctbf08lulu
At any rate, these data support the rationale for using curcumin in preventing and possibly treating AD. While other curcumin products have limited bioavailability, Curcumall is well absorbed and yet is without side effects. The overall feedback of my patients who use Curcumall is very positive. Curcumall assisted many Alzheimer patients who exhibited improvement in their cognitive deficits.
Curcumall, the liquid turmeric/ curcumin C3 extract that is easily absorbed and passes the blood brain barrier. Depending on the severity of the AD condition, it is suggested taking Curcumall 2-3 times daily for a long-term. Each time, one teaspoon of Curcumall in a glass of water, on an empty stomach (half an hour before meals or two hours after meals). Curcumall can also be used by healthy humans as a preventive measure and to assist improvement of cognitive abbilities. In such cases it is recommend taking Curcumall once daily.
For additional information please visit the website:
http://www.curcumall.com/
Alzheimer's disease (AD) involves amyloid beta accumulation in the brain, oxidative damage, and inflammation. Curcumin has anti-oxidant, anti-inflammatory and cholesterol lowering properties, all three of which are believed to be key processes involved in the pathogenesis of AD.
Research has shown that the risk of getting AD is reduced with increased antioxidant and anti-inflammatory consumption. Since curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage and inflammation, it was found that supplementation of curcumin in patients with AD, may inhibit the progression of AD. http://alzheimer.neurology.ucla.edu/pubs/RingmanCurc2005MedChem.pdf
There are a few suggested mechanisms explaining curcumin's activity in AD patients that may inhibit cognitive deficits:
Curcumin was shown to inhibit amyloid accumulation. The peptide called amyloid beta forms aggregates in the brain of AD patients, deposits known as amyloid plaques. Curcumin inhibits the formation of amyloid beta, binds the plaques and thus reduces the amyloid in the brain. http://www.ncbi.nlm.nih.gov/pubmed/15590663
Another research has shown that curcumin helps AD patients by enhancing the natural function of the immune system. Curcumin improved ingestion of amyloid beta by boosting the activity of the immune cells called macrophages. Macrophages are immune system's cells that travel through the body and the brain gobbling up waste products, including amyloid beta. Curcumin may support the body's natural immune fighting function in directly helping the macrophages.
http://www.naturalnews.com/021157_disease_Alzheimers_Alzheimers_disease.html
A third approach has shown that curcumin may reduce amyloid aggregation by a mechanism of metal chelation. As metals can induce amyloid beta aggregation and toxicity and are concentrated in AD brains, curcumin might exert a net protective effect against the amyloid toxicity or might suppress inflammatory damage by preventing metal induction of NF-κB.
http://iospress.metapress.com/content/yy1rf8ctbf08lulu
At any rate, these data support the rationale for using curcumin in preventing and possibly treating AD. While other curcumin products have limited bioavailability, Curcumall is well absorbed and yet is without side effects. The overall feedback of my patients who use Curcumall is very positive. Curcumall assisted many Alzheimer patients who exhibited improvement in their cognitive deficits.
Curcumall, the liquid turmeric/ curcumin C3 extract that is easily absorbed and passes the blood brain barrier. Depending on the severity of the AD condition, it is suggested taking Curcumall 2-3 times daily for a long-term. Each time, one teaspoon of Curcumall in a glass of water, on an empty stomach (half an hour before meals or two hours after meals). Curcumall can also be used by healthy humans as a preventive measure and to assist improvement of cognitive abbilities. In such cases it is recommend taking Curcumall once daily.
For additional information please visit the website:
http://www.curcumall.com/
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